Co-administration of ZYFLO CR with theophylline, warfarin and/or propranolol warrants close monitoring and dosage adjustments of the co-administered drug. Upon initiation of ZYFLO CR in patients receiving theophylline, the theophylline dosage should be reduced by approximately one-half and plasma theophylline concentrations monitored.

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ZYF-Q307-40-01 July 2008.
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